Comparative efficacy of triptans for the abortive.
Triptans are prescription medications used to alleviate migraine episodes. They are specifically indicated for acute migraines and are not used for migraine prevention. Generally, if a person's migraines do not improve with tolerable doses of over-the-counter medications, then prescriptions, including triptans, are considered. Examples include Imitrex (sumatriptan) and Zomig (zolmitriptan).
The safety of triptans for migraine headache was reported in six systematic reviews and meta-analyses,4-9 one RCT,10 and an observer-blind, randomized, parallel-group study.11 The Drug Effectiveness Review Project reported a class review of all formulations of triptans and triptan fixed dose combination products used to treat acute migraine with or without aura.4 Four systematic reviews with.
Although triptans are widely used in the acute management of migraine, there is uncertainty around the comparative efficacy of triptans among each other and vs non-triptan migraine treatments.
The aim of this article is to review the pK and clinical characteristics of these acute care, migraine-specific triptan medications and discuss how their individual characteristics lead to their preferred choice in various clinical scenarios. The pK and clinical efficacy data presented are taken from older published studies in which triptans were compared to placebo or each other, but the.
Triptans, a migraine medication, relieve migraine headache completely within two hours compared to placebo. Ibuprofen was also effective but less well studied. This review was also reassuring in that any side effects of treatment were mild. Most evidence identified in this Cochrane review was for sumatriptan, a commonly prescribed treatment for adults, compared to placebo or dummy pills. A few.
Economic Comparison of Oral Triptans for Management of Acute Migraine: Implications for Managed Care C.E. Reeder, RPh, PhD; Sharm Steadman, PharmD, BCPS, FASHP; and Scott D. Goldfarb, PharmD, MBA Abstract Sound, informed decision making regarding which drugs to include on a formulary should be based on the best available evidence of their clin-ical efficacy and incidence of adverse events.
Acute medicines. Taken when an attack occurs to treat the symptoms. Introduction. The goal of acute migraine treatment is consistent, fast and complete relief of symptoms with reduced disability and without headache recurrence. This makes it important to match the treatment to the level of disability to gain the best possible relief and prompt return to function. To achieve this your doctor.